A RESEARCHER based in Britain claims to have
achieved the biological equivalent of reversing time. She says that
she has perfected a method of creating stem cells from adult cells,
bypassing the ethical dilemma of “therapeutic cloning” which
recently divided the House of Commons.
Although Parliament voted in favour of research into therapeutic
cloning, many people remain uneasy about creating embryos solely for
use as a source of spare parts.
If Ilham Abuljadayel’s claims are verified, treatments for a wide
variety of diseases such as leukaemia, Parkinson’s disease and
Alzheimer’s disease may be transformed. Not only does her method
produce a supply of healthy cells from the patient’s own blood, but
it generates far more cells, more quickly, than alternative methods,
and without raising ethical dilemmas.
So unlikely does the claim seem to many biologists that she has
found it impossible to have it published in leading journals. But
now, she says, it has been replicated by one of the world’s leading
contract research companies, Covance, and a company has been set up
to market the idea.
Stem cells are the forerunners of the mature cells that make up
the organs of the body. They are “pluripotent”, that is, they have
within them the capacity to develop into many different types of
cell — brain, muscle or blood, for example. The simplest source of a
stem cell is a developing embryo, but until now it has been thought
impossible to re-programme a fully developed adult cell and create a
stem cell. That is what Dr Abuljadayel says that she can do.
Born in Saudi Arabia and educated at King’s College London, she
went back to her native country to work as an immunologist. She made
her discovery by accident. She was trying to kill white blood cells
by using a particular antibody when she forgot to add one ingredient
to the mixture.
The result was not dead cells, but cells that had been
transformed into stem cells. She calls the process
retrodifferentiation: a reversal of the normal process by which
immature stem cells differentiate to become mature adult cells.
Since the discovery she has worked to convince others that it is
real. She has used a laboratory in the department of physiology in
Cambridge and presented a seminar there before Christmas.
One leading scientist familiar with her work, Professor Adrian
Newland of the Royal London Hospital Medical School, said that he
had repeated her experiments with the same results.
“It’s fascinating, but there could be other explanations for what
is going on,” he said. “My own work suggests that it isn’t possible
to reverse the process of differentiation, but I have repeated her
work and got similar results. I think more research needs to be done
to eliminate other possible explanations. As it stands, it could be
amazing, or it could be inconsequential.”
The first clinical application of the technique could be in
treating leukaemia.
Dr Abuljadayel says that blood would be taken from the patient
and treated to create a population of new stem cells, a process that
takes only a few hours.
The patient would then be treated with drugs or radiation to
destroy the bone marrow cells and kill the cancer, before
repopulating the bone marrow with cells generated from the stem
cells.
Dr Abuljadayel’s husband, Ghazi Dhout, who is president of
Tristem, the Dublin-based company set up to exploit the discovery,
says that a big advantage is that a huge volume of cells can be
generated.
He says that the first trials, on individual patients, might
start in the next six months.The company plans to seek partners
among the big drug and biotech companies to develop the business.
The invention is patented.
A cure for leukaemia may be possible with the discovery of an
immune cell that can seek and destroy infected cells. The
development was announced by researchers at London’s Hammersmith
Hospital and the Imperial College of Medicine, who have spent six
years investigating the disease.